UR-144 Degradant

NameUR-144 Degradant
Formal Name(1-​pentyl-​1H-​indol-​3-​yl)(2,​2,​3,​3-​tetramethylcyclopropyl)-​methanone
InChI CodeInChI=1S/C21H29NO/c1-6-7-10-13-22-14-16(15-11-8-9-12-17(15)22)18(23)19-20(2,3)21(19,4)5/h8-9,11-12,14,19H,6-7,10,13H2,1-5H3
DescriptionUR‐144 is a tetramethylcyclopropyl (TMCP) synthetic cannabinoid analog which has become a popular unregulated replacement for previous generation synthetic cannabinoids that have been recently regulated in the United States.Invented by Abbott Laboratories for pharmaceutical applications, UR‐144 shows higher affinity for the CB2 receptor over the CB1 receptor. GCMS spectral data has been presented for UR‐144 as well as other TMCP cannabinoid analogs such as XLR‐11 and A‐796,260. Common to all of these analyses is the presence of an impurity related to the parent TMCP compound. In all cases, the impurity possesses a similar spectrum to its parent TMCP compound with the exception that there is a prominent fragment ion 15amu higher than the parent compound’s Base Peak ion. Furthermore, unpublished reports suggest that in the case of A‐796,260, the impurity may be more prominent in burned samples compare to unburned samples.


Submitted ByCayman Chemical
Defense Forensic Science Center, United States Army Criminal Investigation Laboratory (USACIL), Forest Park, Georgia
Marshall University, Huntington, WV
ContactPaul D. Kennedy, PhD. at Cayman Chemical
Product DetailsLink


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